Latest Edition
 

Page Visit Counter
Visitors: 36,155

 

Featured Article:

 

Material And Tableting Properties Of Theophylline Solid Dispersions

 
  (Vol. 6 Number 1) by Oluwaseun A. Orugun1, Adeniji K. Olowosulu1, Olubunmi J. Olayemi2,  
     
 


This study was carried out to evaluate the material and tableting properties of theophylline solid dispersions (SDs) prepared by the solvent evaporation technique using Eudragit polymers (RS 100 & RSPO) as carriers. The dispersions were directly compressed into tablets using microcrystalline cellulose (MCC) as filler/binder. Compatibility studies of the prepared dispersions were conducted using FTIR, DSC and TLC while physico-technical properties of the tablets were evaluated. Results of compatibility studies revealed no chemical interaction between theophylline and the selected polymers. All the tablet properties evaluated were in conformity with the USP specifications. In vitro drug release was observed to be prolonged for about 24 h and the mechanism of drug release was principally by diffusion. Stability studies showed that drug content of all the tablets remained within the official specifications after three months. Overall, the material properties of the SDs were consistent with good tableting properties as confirmed by the tablets produced.
Keywords: Solid dispersion, tablets, direct compression, Eudragit®RS100, Eudragit®RS PO, drug release


 
     
  PDF ButtonDownload PDF (Right-Click and Click "Save As") (748.26kb)  
     

*You need Adobe Acrobat Reader to view this Document

*If you cannot view or open this document, please download and Install Acrobat Reader via the link below

Adobe Acrobat Reader

 


| Powered by PenielBiz
Home | About | Archive | Pulication Guide | Editorial TeamEnquiries | Admin Login | Email Login