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Comparative Study On Anti-inflammatory And Analgesic Effects Of The Leaf, Stem And Root Of dracaena Arborea (wild) Linn. (asparagaceae)

  (Vol. 9 Number 2) by 1*uwemedimo Umoh, 1paul Thomas 2jude Okokon, 3kola’ Ajibesin And 4olorunfemi Eseyin  

Dracaena arborea is one of the plants used in Akwa Ibom State ethnomedicine to treat pain and inflammatory related diseases. This research was structured to study the anti-inflammatory and analgesic abilities of the leaf, stem and root of D. arborea. The leaf, stem and root of D. arborea plant were collected, garbled, dried, pulverized, macerated with 70% ethanol for 72 hours, filtered and concentrated. The LD50 of the extracts was studied using the method described by Lorke; anti-inflammatory study was carried out using egg albumin-induced oedema and xylene-induced topical oedema models while analgesic study was done using acetic acid-induced writhing, formalin-induced paw licking and hot plate-induced pain models. The result of the study revealed the LD50 of 223.60 mg/kg, 273.86 mg/kg and 122.47 mg/kg for the leaf, stem and root extracts, respectively. Also, the leaf, stem and root extracts of D. arborea were able to reduce oedema caused by egg albumin and xylene; exhibited high analgesic properties in inhibiting pain induced by formalin, acetic acid and hot plate. These reductions were dose-dependent and statistically significant (p < 0.05) when compared to distilled water and similar to prototype drugs, acetyl salicylic acid and dexamethasone. The result from this study supports D. arborea as anti-inflammatory and analgesic agent in ethnomedicine

Keywords: Comparative, Anti-inflammatory, Analgesic and Effects

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