Latest Edition

Page Visit Counter
Visitors: 61,398


Featured Article:


Synthesis, Characterization And Antimicrobial Screening Of Mixed 5-(4-chlorophenyl)-6-ethyl- 2,4pyrimidinediamine-aspirin Metal Drug Complexes

  (Vol. 8 Number 1) by Bamigboye, Mercy Oluwaseyi,1* Lawal, Misitura,2 Nnabuike, Ginikachukwu Grace3  

A new series of complexes of 5-(4-chlorophenyl)-6-ethyl- 2,4-pyrimidinediamine-aspirin metal drug has been synthesized as potential antimalarial and analgesic activity which yielded excellent results. The synthesized complexes have been evaluated using some analytical techniques such as conductivity measurements, elemental analysis and spectroscopic analysis such as atomic absorption spectroscopy and FT-IR. The result of the conductivity measurement showed the compounds to be non-electrolyte and suggests a tetrahedral geometry. The ligands used are bidentate in nature. In pyrimethamine complexes, coordination occurred through the nitrogen of the N-H and C=N groups as seen in the results obtained from the FT-IR analysis. In aspirin, the coordination occurred through the oxygen of the C=O and O-H group. The novel complexes have been screened and investigated against some isolated organisms namely: Escherichia coli, Bacillus megaterium, Proteus vulgarius, Pseudomonas aeruginosa, Euterobacter aerogenes, Staphylococcus aureus, Bacillus substillis and Serratia marcesceus. Higher activity was observed due to ability to decrease the population of the bacterial species. This research work was carried out with the aim of improving the effectiveness and antibacterial activity of the parent ligands .

Keywords: Transition Metals, Pyrimethamine, Aspirin, Complexes, FT-IR, Anti-bacterial.

  PDF ButtonDownload PDF (Right-Click and Click "Save As") (436.80kb)  

*You need Adobe Acrobat Reader to view this Document

*If you cannot view or open this document, please download and Install Acrobat Reader via the link below

Adobe Acrobat Reader


| Powered by PenielBiz
Home | About | Archive | Pulication Guide | Editorial TeamEnquiries | Admin Login | Email Login